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Breast cancer and importance of zygosity determination in triplet sisters
H T Lynch1, P Watson, T Conway
1Creighton University School of Medicine, Department of Preventive Medicine, Omaha, Nebraska, USA.
Breast Cancer Research and Treatment
|January 1, 1995
Abstract:
This study is the first to examine the genetic risk in a breast cancer-prone family wherein two of three triplet sisters and their mother manifested breast cancer. The unaffected triplet, the proband, was found to be monozygotic with her deceased sister through DNA testing of tumor blocks and dizygotic to her living affected sister. Genetic counseling implications are discussed.