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End organ function with prolonged nonpulsatile circulatory support

R C Reddy1, A H Goldstein, J J Pacella

  • 1Department of Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1995
PubMed
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Long-term use of a nonpulsatile centrifugal pump for circulatory support proved safe in sheep, showing no end-organ dysfunction. This inexpensive device shows promise as a ventricular assist device.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research

Background:

  • Ventricular assist devices (VADs) are crucial for managing heart failure.
  • Nonpulsatile circulatory support is an area of ongoing research for VADs.

Purpose of the Study:

  • To evaluate the safety and efficacy of long-term circulatory support using a nonpulsatile centrifugal pump.
  • To assess for end-organ dysfunction in animals receiving continuous circulatory support.

Main Methods:

  • Implantation of a small, inexpensive centrifugal pump (7 L/min capacity) in 6 sheep.
  • Cannulation of the left atrium and anastomosis to the descending aorta.
  • Monitoring of pump performance and physiological parameters, with end-organ function analysis at 28 days.

Main Results:

Related Experiment Videos

  • Four sheep survived beyond 4 weeks, demonstrating adaptation to pulseless circulatory support.
  • No neurologic dysfunction was observed.
  • Biochemical markers showed no significant end-organ dysfunction, with some parameters improving post-implantation (e.g., hemoglobin, total protein).

Conclusions:

  • Long-term nonpulsatile circulatory support with a centrifugal pump is safe and does not cause end-organ dysfunction in this ovine model.
  • The findings support the development of inexpensive, implantable centrifugal pumps as ventricular assist devices.