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A new fiber optic probe for cellular visualization

R D Schaub1, H S Borovetz, S J Morgan

  • 1Department of Bioengineering, School of Engineering, University of Pittsburgh, Pennsylvania, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1995
PubMed
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A new fiber optic probe visualizes blood flow and cell deposition in artificial organs, aiding thrombosis detection. This technology helps understand blood flow issues within medical devices.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Fluid Dynamics

Background:

  • Thrombus formation in artificial organs is linked to impaired blood flow.
  • Accurate visualization of blood flow and cellular deposition is crucial for device development.

Purpose of the Study:

  • To develop a compact fiber optic probe for visualizing particle flow and cellular deposition.
  • To assess the probe's capability in detecting thrombosis within artificial organs.

Main Methods:

  • A magnifying fiber optic probe with a small cross-section was constructed using a germanium oxide fiber optic bundle and a gradient index lens.
  • Fluorescent microspheres (3-48 microns) and labeled human platelets were used to visualize flow and deposition.
  • Flow dynamics of microspheres in buffer with varying hematocrits (10-45%) were studied.

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Main Results:

  • The probe successfully imaged fluorescent microspheres of different sizes.
  • Blood flow dynamics, including 3-micron microsphere movement in suspensions with varying hematocrits, were visualized.
  • Platelet deposition from stagnant conditions was observed, indicating potential for thrombosis detection.

Conclusions:

  • The developed fiber optic probe can visualize particle flow and cellular deposition in confined spaces.
  • This technology shows promise for assessing blood flow and detecting thrombosis in artificial organs.
  • The probe offers a method for local flow quantification within medical devices.