Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does interleukin-1 induce hair loss?

R Hoffmann1, R Happle

  • 1Department of Dermatology, Philipp University, Marburg, Germany.

Dermatology (Basel, Switzerland)
|January 1, 1995
PubMed
Summary

Interleukin-1 (IL-1) may induce hair loss by inhibiting hair growth. Aberrant IL-1 expression is linked to alopecia areata, suggesting IL-1

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frontal fibrosing alopecia sparing a dermal melanocytic nevus: a report of two cases of Renbök phenomenon.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

White lentiginosis of Grosshans: which mode of inheritance?

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Phylloid hypermelanosis: further report of an unusual syndrome.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Two examples of Renbök phenomenon in dermatophytosis sparing congenital nevi.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

A proposed new category of cutaneous segmental mosaicism: Isolated segmental biallelic monoclonal mosaicism.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Flag-like hypermelanosis with superimposed lichen sclerosus et atrophicus: an unusual Koebner phenomenon?

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Area of Science:

  • Dermatology and immunology, focusing on skin physiology and hair follicle biology.

Background:

  • Cytokines are crucial in skin physiology and pathophysiology.
  • Interleukin-1 (IL-1) is implicated in various hair diseases and hair loss.
  • Aberrant IL-1 beta expression is observed in alopecia areata scalp areas.

Purpose of the Study:

  • To investigate the role of Interleukin-1 (IL-1) in regulating human hair growth.
  • To explore IL-1 as a potential mediator of hair loss in dermatological conditions.

Main Methods:

  • Review of clinical and experimental data on IL-1 and hair growth.
  • In vitro studies assessing IL-1's effect on human hair growth.
  • Analysis of gene overexpression models (IL-1 alpha) in mice for hair loss phenotypes.

Main Results:

  • Interleukin-1 (IL-1) acts as a potent inhibitor of human hair growth in vitro.
  • Overexpression of the interleukin-1 alpha gene in mice leads to patchy hair loss.
  • Aberrant expression of interleukin-1 beta is detected in alopecia areata affected scalp areas.

Conclusions:

  • Interleukin-1 (IL-1) is hypothesized to be a critical mediator that induces the cessation of hair growth.
  • IL-1's role in hair loss warrants further investigation for therapeutic targets in hair diseases.

Related Experiment Videos