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Continuous hemofiltration as blood purification in sepsis
1Department of Anaesthesia and Intensive Care, Austin Hospital, Melbourne, Victoria, Australia.
New Horizons (Baltimore, Md.)
|November 1, 1995
Summary
Continuous hemofiltration, a blood purification technique, effectively removes harmful molecules like cytokines and inflammatory mediators in critically ill patients. This therapy shows promise in improving hemodynamics and cardiac function, offering a potential adjunctive treatment for severe sepsis.
Area of Science:
- Nephrology
- Intensive Care Medicine
- Critical Care
Background:
- Continuous hemofiltration (CHF) evolved from renal replacement therapy.
- Blood purification is gaining traction for managing sepsis and septic shock.
- Soluble mediators contribute to organ injury in sepsis.
Purpose of the Study:
- To explore the role of continuous hemofiltration in sepsis.
- To investigate the removal of inflammatory molecules during CHF in septic patients.
- To assess the hemodynamic and cardiac effects of CHF in sepsis.
Main Methods:
- In vivo studies in humans and animals undergoing continuous hemofiltration.
- Measurement of cytokine and other soluble molecule removal.
- Assessment of hemodynamic parameters and cardiac function.
Main Results:
- Continuous hemofiltration effectively removes cytokines, platelet-activating factor, complement factors (C5a, C3a), and thromboxane.
- Beneficial hemodynamic effects observed in septic animals, correlating with ultrafiltration intensity.
- Improved cardiac function and removal of myocardial depressant factors noted.
Conclusions:
- Continuous hemofiltration demonstrates efficacy in removing noxious molecules during sepsis.
- The therapy shows potential for improving hemodynamic stability and cardiac function in septic patients.
- Continuous hemofiltration may serve as a valuable adjunctive treatment for severe sepsis.