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Updated: Aug 6, 2026
09:54
Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases
Published on: December 26, 2011
Neoglycoconjugates and their applications in glycobiology
1University of British Columbia, Vancouver, Canada.
Current Opinion in Structural Biology
|October 1, 1995
Summary
New methods for neoglycoconjugate formation improve the analysis of glycan structure and function. These chemical and enzymatic techniques enable tagging of oligosaccharides for diverse applications.
Area of Science:
- Carbohydrate Chemistry
- Glycobiology
- Bioconjugation
Background:
- Neoglycoconjugates are essential tools for studying carbohydrate structure and function.
- Recent advancements have enhanced the accessibility and utility of these probes.
Purpose of the Study:
- To review recent developments in neoglycoconjugate formation.
- To highlight simple chemical and enzymatic methods for tagging oligosaccharides.
- To present representative applications of neoglycoconjugates.
Main Methods:
- Chemical methods for oligosaccharide tagging.
- Enzymatic approaches for oligosaccharide modification.
- Conjugation of oligosaccharides to various labels (chromophores, biotin, peptides, proteins, lipids).
Main Results:
- Increased accessibility and improved usefulness of neoglycoconjugates.
- Demonstration of diverse tagging strategies for oligosaccharides.
- Successful application of neoglycoconjugates in glycan analysis.
Conclusions:
- Neoglycoconjugate formation techniques have significantly advanced.
- These methods provide powerful tools for exploring glycan roles.
- Neoglycoconjugates are valuable for analyzing glycan structure and function.
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