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Diffuse bone marrow uptake [123I]MIBG in neuroblastoma: an "MIBG super scan" case report
F Giammarile1, A L Olier, J Lumbroso
1Service de Médecine Nucléaire, Institut Gustave Roussy, Villejuif, France.
The Quarterly Journal of Nuclear Medicine : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR)
|June 1, 1995
Abstract:
We present the case of a 3-year-old child with neuroblastoma metastatic to the bone marrow. [123I]MIBG total body scintigraphy revealed a diffuse pattern of intense fixation throughout the skeleton. This was analogous to the "super scan" described with 99mTc-MDP bone scintigraphy when extensive metastatic or metabolic bone disease is present. Essentially, a high bone-to-soft tissue ratio was found without uptake in the liver, kidney and bladder, owing to a "steal" mechanism caused by the avid bone metastases.