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Related Experiment Videos

An age-related decrease in the concentration of insulin-like growth factor binding protein-5 in human cortical bone

V Nicolas1, S Mohan, Y Honda

  • 1Jerry L. Pettis Memorial Veterans Hospital, Loma Linda, California 92357, USA.

Calcified Tissue International
|September 1, 1995
PubMed
Summary
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Bone contains insulin-like growth factor-2 (IGF-II) and binding proteins. IGFBP-5 decreases with age, correlating with IGF-II and other growth factors like IGF-I and TGF-beta.

Area of Science:

  • Biochemistry
  • Orthopedics
  • Gerontology

Background:

  • Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) play crucial roles in bone metabolism.
  • Understanding the age-related changes in skeletal IGFs and IGFBPs is vital for bone health research.

Purpose of the Study:

  • To quantify the skeletal content of IGF-II, IGFBP-5, and IGFBP-3 in human femoral cortical bone.
  • To investigate the relationship between the content of these factors and age.
  • To explore correlations between IGF-II, IGFBP-5, IGFBP-3, and previously measured IGF-I and TGF-beta.

Main Methods:

  • Human femoral cortical bone samples were obtained from 64 subjects (ages 20-64).
  • Skeletal content of IGF-II, IGFBP-5, and IGFBP-3 was determined quantitatively.

Related Experiment Videos

  • Statistical analyses, including correlation coefficients (r) and p-values, were used to assess relationships.

    • Main Results:

    • A significant age-related decrease was observed in femoral cortical IGFBP-5 content (r = -0.272, P = 0.031).
    • Femoral cortical IGF-II content did not decrease with age but correlated positively with IGFBP-5 (r = 0.442, P < 0.001).
    • Femoral cortical IGFBP-3 content showed no age-related decrease and no correlation with IGF-II or IGFBP-5.

    Conclusions:

    • IGFBP-5 content in human femoral cortical bone declines with age.
    • IGF-II and IGFBP-5 levels in bone are interrelated, suggesting a functional connection.
    • IGFBP-5, but not IGFBP-3, correlates with other bone-related growth factors (IGF-I, TGF-beta), highlighting its potential role in bone aging.