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Tissue utilization at the Minnesota Lions' Eye Bank

A L Moyes1, E J Holland, F E Palmon

  • 1Department of Ophthalmology, University of Minnesota, Minneapolis 55455, USA.

Cornea
|November 1, 1995
PubMed
Summary
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This study reviewed cornea utilization, finding donor age over 75 and poor tissue quality were primary exclusion reasons. Reevaluating these criteria could increase available corneas for transplantation.

Area of Science:

  • Ophthalmology
  • Transplantation Science
  • Public Health

Background:

  • Eye banks play a crucial role in providing corneas for transplantation.
  • Optimizing cornea utilization is essential to meet the growing demand for sight-saving procedures.

Purpose of the Study:

  • To analyze cornea exclusion reasons at the Minnesota Lions' Eye Bank.
  • To identify strategies for increasing the supply of transplantable corneas.

Main Methods:

  • Retrospective chart review of 2,382 corneas evaluated between December 1992 and November 1993.
  • Categorization of exclusion criteria including donor age, medical history, and tissue quality.

Main Results:

  • Only 31% of procured corneas were suitable for transplantation; 67% were used for research/training.

Related Experiment Videos

  • Major exclusion reasons included donor age (>75 years, 40%), medical history contraindications (24%), and poor tissue quality (24%).
  • Specular microscopy abnormalities were the most common tissue quality issue, while low endothelial cell counts were infrequent reasons for rejection.

    • Conclusions:

    • Current exclusion criteria, particularly donor age and certain tissue quality parameters, warrant reevaluation.
    • Revising policies on epithelial defects and arcus senilis, and further investigating specular microscopy findings, may enhance cornea availability.
    • Improving procurement timeliness and reassessing age and postsurgical exclusions are potential avenues for increasing transplantation rates.