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Effect of partial pressure on solubility of isoflurane in blood
G M Xie1, R Lauber, A M Zbinden
1Institute for Anaesthesiology and Intensive Care, University Hospital, Bern, Switzerland.
Abstract:
The effect of partial pressure of isoflurane on its solubility in blood of different haematocrit was determined at different isoflurane partial pressures, using a syringe--flask method and gas chromatography with blood from one donor. The solubility of isoflurane decreased with increasing blood haematocrit (39.5%, 51.9% and 61.9%) and isoflurane partial pressure from 1 MAC to 4 MAC. The solubility in 50% and 60% haematocrit blood at 2, 3 and 4 MAC was significantly different from the solubility in normal blood at 1 MAC (P < 0.05). We conclude that the solution of isoflurane in blood (especially in high haematocrit blood) does not obey Henry's law.