Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elastin in blood vessels

L Robert1, M P Jacob, T Fülöp

  • 1Laboratoire de Biologie Cellulaire, Equipe de Biochimie du Tissu Conjonctif, Université Paris VII-Denis Diderot, France.

Ciba Foundation Symposium
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Presentation.

Pathologie-biologie·2012
Same author

Celebration of the 50th anniversary of the foundation of the French society for connective tissue research. Its short history in the frame of the origin and development of this discipline.

Pathologie-biologie·2012
Same author

Fifty years of structural glycoproteins.

Pathologie-biologie·2012
Same author

[Pathologie Biologie: an evolution].

Pathologie-biologie·2011
Same author

Physiology of skin aging.

Clinics in plastic surgery·2011
Same author

The Maillard reaction--illicite (bio)chemistry in tissues and food.

Pathologie-biologie·2011
Same journal

Precision agriculture: spatial and temporal variability of environmental quality. General reflections.

Ciba Foundation symposium·1997
Same journal

Uncertainty in hydrogeological modelling.

Ciba Foundation symposium·1997
Same journal

Optimal mapping of site-specific multivariate soil properties.

Ciba Foundation symposium·1997
Same journal

Modelling for precision weed management.

Ciba Foundation symposium·1997
Same journal

GIS support for precision agriculture: problems and possibilities.

Ciba Foundation symposium·1997
Same journal

Spatial sampling.

Ciba Foundation symposium·1997
See all related articles

Aging impairs blood vessel function through elastin degradation, leading to circulating elastin peptides. These peptides interact with receptors, promoting vascular issues and calcification.

Area of Science:

  • Vascular Biology
  • Biochemistry
  • Cardiovascular Research

Background:

  • Elastin fibers are crucial for blood vessel rheological properties, including elastic recoil.
  • Aging leads to increased calcium and lipid content, and elastolytic degradation of elastin fibers, impairing vascular function.
  • This degradation results in circulating elastin peptides.

Purpose of the Study:

  • To investigate the role of circulating elastin peptides and their interaction with the elastin receptor in vascular dysfunction.
  • To understand the mechanisms linking elastin degradation, receptor activity, and age-dependent vascular changes like calcification.

Main Methods:

  • Analysis of elastin fiber degradation and circulating elastin peptide levels.
  • Investigation of elastin receptor interactions on smooth muscle cells.

Related Experiment Videos

  • Assessment of monocyte involvement in atherogenesis.
  • Evaluation of calcium homeostasis and vascular calcification.

    • Main Results:

    • Circulating elastin peptides interact with the elastin receptor on smooth muscle cells.
    • This interaction promotes cell-elastin fiber adhesion and endothelium-dependent vasorelaxation.
    • It also triggers the release of lytic enzymes and oxygen free radicals from monocytes.
    • Age-dependent uncoupling of the elastin receptor is linked to impaired calcium homeostasis and vascular calcification.

    Conclusions:

    • Elastin degradation and subsequent peptide formation are key contributors to age-related vascular dysfunction.
    • The elastin receptor plays a critical role in mediating these effects, influencing smooth muscle cell behavior and monocyte activity.
    • Dysregulation of the elastin receptor contributes to the loss of calcium homeostasis and progressive vascular calcification.