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Related Experiment Videos

Chronically denervated rat carotid bodies

A Hess

    Acta Anatomica
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Severing the ninth nerve in rats had minimal effects on the carotid body. Glomus cells showed no pathological changes, and catecholamine content remained stable after denervation.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Physiology

    Background:

    • The carotid body is a sensory organ crucial for regulating respiration and cardiovascular function.
    • Understanding the impact of denervation on the carotid body is vital for comprehending its physiological resilience.
    • Previous research suggests potential structural and functional alterations following nerve damage.

    Purpose of the Study:

    • To investigate the morphological and biochemical consequences of ninth nerve severance on the rat carotid body.
    • To assess the impact of deafferentation on glomus cells and associated catecholamine content.
    • To compare the response of carotid body cells to deafferentation with other sensory receptor cells.

    Main Methods:

    • Surgical severance of the ninth cranial nerve in rats.

    Related Experiment Videos

  • Light and electron microscopy for morphological analysis.
  • Formaldehyde-induced fluorescence to quantify catecholamine levels.
  • Histological examination at various time points post-operation (3 weeks to 13 months).

    • Main Results:

    • Minimal morphological changes observed in the carotid body post-denervation.
    • Transient hypertrophy of capsule cells noted up to 2 months, followed by normalization.
    • Increased frequency and size of lysosomes in capsule cells.
    • No discernible pathological alterations in glomus cells despite lack of afferent innervation.
    • Comparable catecholamine content in denervated and innervated carotid bodies.
    • Absence of nerve terminals on glomus cells; intrinsic ganglion cells likely innervate blood vessels.

    Conclusions:

    • Deafferentation of the carotid body by ninth nerve severance results in minimal morphological effects.
    • Glomus cells exhibit remarkable resilience to the loss of afferent nerve terminals.
    • The study provides insights into the adaptive capacity of the carotid body and its cellular components.