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Developmental failure in preimplantation human conceptuses

¹Laboratoire de Physiologie du Developpement, Institut Jacques Monod, CNRS-Université Paris VII, France.

International Review of Cytology

|January 1, 1996

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Most human embryos created in vitro fail to implant. This may be due to poor oocyte quality and cellular abnormalities observed in early human development, impacting pregnancy success.

Area of Science:

Reproductive Biology
Developmental Biology
In Vitro Fertilization

Background:

Most human embryos created via in vitro fertilization (IVF) fail to establish pregnancy after uterine transfer.
Embryo transfer typically occurs after only one or two cell divisions, limiting knowledge of their developmental potential.
A significant proportion of fertilizable human oocytes possess chromosomal abnormalities, irrespective of ovarian stimulation.

Purpose of the Study:

To investigate the causes of early human conceptus demise.
To determine the contribution of oocyte quality to implantation failure.
To assess the impact of in vitro conditions on early embryonic development.

Main Methods:

Analysis of chromosomal status in human oocytes.

Related Experiment Videos

Evaluation of cellular organization and abnormalities in preimplantation-stage conceptuses developed in vitro.

Comparison of in vitro and in vivo fertilized conceptuses.

Main Results:

Preimplantation human conceptuses developed in vitro exhibit a high incidence of cellular abnormalities.
Similar disruptions in cellular organization are observed in conceptuses fertilized in vivo.
Poor oocyte quality is implicated as a potential cause of developmental abnormalities and conceptus demise.

Conclusions:

Developmental abnormalities and early conceptus demise may originate from poor oocyte quality.
In vitro conditions might contribute to or cause the early demise of human conceptuses.
Further research is needed to improve IVF success rates by addressing oocyte and embryo quality.