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Postoperative nausea vomiting (PONV): influence of bowel manipulation during intraabdominal surgery
1Department of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
This study does not confirm the hypothesis that "bowel manipulation during intraabdominal surgery may release 5 HT3 to stimulate the vomiting center via the vagus nerve". Thus routine prophylactic use of 5 HT3 receptor antagonist is probably not necessary, especially in Thai patients whose PONV is not distinct both in incidence and intensity of emesis.
This study does not confirm the hypothesis that "bowel manipulation during intraabdominal surgery may release 5 HT3 to stimulate the vomiting center via the vagus nerve". Thus routine prophylactic use of 5 HT3 receptor antagonist is probably not necessary, especially in Thai patients whose PONV is not distinct both in incidence and intensity of emesis.