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Multiphasic prolactin secretion during parturition in human subjects

L A Rigg, S S Yen

American Journal of Obstetrics and Gynecology

|May 15, 1977

Summary

Prolactin (PRL) secretion shows a unique multiphasic pattern during labor and vaginal delivery, unlike cesarean births. This pattern is linked to neuroendocrine processes during childbirth.

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Area of Science:

Reproductive Endocrinology
Neuroendocrinology

Background:

Prolactin (PRL) secretion patterns during the periparturitional period are not fully understood.
Previous studies have not detailed the specific dynamics of PRL secretion in relation to labor and delivery methods.

Purpose of the Study:

To investigate the distinct patterns of prolactin secretion in women during labor and vaginal delivery compared to elective cesarean section.
To explore potential correlations between PRL secretion patterns and other hormonal changes or external stimuli during parturition.

Main Methods:

Observational study measuring serum prolactin levels at various time points during labor, delivery, and the postpartum period.
Comparison of PRL secretion patterns between patients undergoing vaginal delivery and those undergoing elective cesarean section.
Correlation analysis with serum concentrations of cortisol, progesterone, estradiol, and estrone.

Main Results:

A distinct multiphasic PRL secretion pattern was observed in patients undergoing labor and vaginal delivery, characterized by a decline during labor, a surge post-delivery, and subsequent fall.
This pattern was absent in patients who underwent elective cesarean section without labor.
PRL levels were not correlated with cortisol, progesterone, estradiol, or estrone, and were unaffected by analgesics, anesthesia, or surgical stress.

Conclusions:

Prolactin secretion in term pregnancy is largely unresponsive to common stimuli like analgesia or surgical stress.
The unique multiphasic PRL secretion pattern associated with labor and vaginal delivery suggests a specific role for dopaminergic neuroendocrine processes in human parturition.

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