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Subdermal levonorgestrel implants. Three years' experience in Cairo, Egypt

D E Rizk1

  • 1Department of Obstetrics and Gynaecology, Llandough Hospital, Cardiff, Wales.

The Journal of Reproductive Medicine
|September 1, 1995
PubMed
Summary
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The subdermal levonorgestrel implant (SLI) is a safe and effective contraceptive. This study shows a low pregnancy rate over three years, with menstrual changes being the main side effect.

Area of Science:

  • Reproductive Health
  • Contraception
  • Endocrinology

Background:

  • Long-acting reversible contraceptives (LARCs) are crucial for family planning.
  • Subdermal levonorgestrel implant (SLI) offers a low-dose, progestin-only LARC option.

Purpose of the Study:

  • To evaluate the efficacy, safety, and acceptability of the subdermal levonorgestrel implant (SLI).
  • To assess the SLI as a novel, long-acting, low-dose, progestin-only contraceptive method for women.

Main Methods:

  • Prospective, observational study.
  • Advanced phase III clinical trial conducted in a family planning clinic.
  • Follow-up of 350 women over three years.

Main Results:

  • A net three-year cumulative pregnancy rate of 0.98% was observed.

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  • Menstrual disturbances (amenorrhea, menorrhagia) were the primary side effects, affecting 25% in the third year.
  • Continuation rate after three years was 65.5%, with removals mainly due to menstrual issues or other medical/insertion site complications.
  • Conclusions:

    • The subdermal levonorgestrel implant demonstrates high efficacy and safety.
    • The SLI is an acceptable contraceptive option with a favorable safety profile.
    • The implant represents a valuable addition to available contraceptive methods.