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Enflurane metabolism and postoperative renal function

V Weiss, C de Carlini

    Der Anaesthesist
    |March 1, 1977
    PubMed
    Summary
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    This study measured inorganic fluoride levels in gynaecological patients during and after enflurane anesthesia. Post-operative renal function remained unaffected despite elevated urine fluoride concentrations.

    Area of Science:

    • Anesthesiology
    • Clinical Chemistry

    Background:

    • Enflurane is an inhalational anesthetic agent.
    • Concerns exist regarding potential renal toxicity from fluoride, a metabolite of enflurane.

    Purpose of the Study:

    • To investigate inorganic fluoride concentrations in blood and urine during and after enflurane anesthesia.
    • To assess post-operative renal function in patients undergoing gynecological surgery.

    Main Methods:

    • Blood and urine samples were collected from 22 gynecological patients.
    • Patients received either 0.6% or a mixture of 0.6% and 0.8% enflurane.
    • Serum fluoride levels were measured at various time points; renal function was monitored post-operatively.

    Main Results:

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  • Serum fluoride concentrations in arterial blood reached 18.99 µmol/L (Group I) and 21 µmol/L (Group II) after 120 minutes.
  • Venous blood fluoride levels were similar in both groups one hour post-anesthesia and decreased over 12 hours.
  • Elevated postoperative urinary fluoride concentrations were observed in all patients.

    • Conclusions:

    • Enflurane anesthesia leads to measurable increases in serum and urine fluoride levels.
    • No evidence of renal dysfunction was detected in the patients following anesthesia.
    • The study suggests that enflurane anesthesia, at the tested concentrations, does not impair renal function.