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Isoforms of glucose transporter in the iris-ciliary body
H Tsukamoto1, H K Mishima, T Kurokawa
1Department of Ophthalmology, Hiroshima University School of Medicine, Japan.
Japanese Journal of Ophthalmology
|January 1, 1995
Abstract:
Isoforms of the facilitated glucose transporter (GLUT) were identified in the iris-ciliary body. Western blot analysis showed that GLUT1 and GLUT4 proteins were expressed in the rat iris-ciliary body. In addition, the content of GLUT proteins in the rabbit iris-ciliary body was estimated by specific [3H]cytochalasin B binding assay. The content of GLUT proteins was found to be more abundant in the iris-ciliary body than in the cerebral cortex. The utilization of glucose in the iris-ciliary body and the transport of glucose into the aqueous humor are suggested to be mediated by GLUT1 and GLUT4 proteins.