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Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

[The clinical picture of mycotic complications in HIV-infected patients]

A G Rakhmanova, O Kh Giaurgieva, G I Gorshkov

    Klinicheskaia Meditsina
    |January 1, 1995
    PubMed

    Insights

    Mycotic complications are common in HIV-infected individuals, increasing with immunodeficiency. Oropharyngeal candidiasis often precedes other fungal infections like candidemia and meningoencephalitis.

    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Immunocompromised Host Research

    Context:

    • Human Immunodeficiency Virus (HIV) infection significantly impairs the immune system.
    • HIV-associated immunodeficiency creates vulnerability to opportunistic infections.
    • Fungal infections (mycoses) represent a major category of opportunistic diseases in this population.

    Purpose:

    • To investigate the prevalence and spectrum of mycotic complications in HIV-infected subjects.
    • To determine the relationship between immunodeficiency progression and the incidence/severity of fungal infections.
    • To identify the etiological agents responsible for mycoses in this cohort.

    Summary:

    • Mycotic complications were observed in 21 of 37 HIV-infected subjects.
    • Oropharyngeal candidiasis was the most frequent presentation, often preceding other forms such as esophageal, skin candidiasis, fungemia, meningoencephalitis, and disseminated lesions.
    • The prevalence and severity of mycoses correlated with the degree of immunodeficiency.
    • A wide range of fungi were identified, including Candida species (albicans, krusei, tropicalis, pseudotropicalis, parapsilosis), Cryptococcus neoformans, Rhodotorula rubra, and Penicillium chrysogenum.

    Impact:

    • Highlights the significant burden of fungal infections in HIV patients.
    • Underscores the importance of monitoring for mycoses as an indicator of immune status.
    • Provides data on the diversity of fungal pathogens encountered in this population.
    • Informs clinical management strategies for opportunistic infections in HIV care.

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