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Profactor-H (elevated circulating insulin): the link to health risk factors and diseases of civilization

R F Heller1, R F Heller

  • 1Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA.

Medical Hypotheses
|October 1, 1995
PubMed

Insights

Profactor-H, or chronic elevated circulating insulin, is linked to numerous diseases. Lifestyle changes, including reduced carbohydrate intake, chromium supplementation, activity, and stress reduction, can mitigate its health impacts.

Area of Science:

  • Metabolic Health
  • Endocrinology
  • Disease Etiology

Background:

  • Chronic elevated circulating insulin, termed Profactor-H, is prevalent in conditions like atherosclerosis, hypertension, type 2 diabetes, obesity, and cardiovascular diseases.
  • Profactor-H is identified as a central pathophysiological factor in the development of numerous diseases and health risks.
  • Factors influencing Profactor-H include genetics, high refined carbohydrate consumption, chromium deficiency, sedentary lifestyle, and stress.

Purpose of the Study:

  • To introduce and define the term Profactor-H for chronic elevated circulating insulin.
  • To highlight Profactor-H's significant role in the etiology of various chronic diseases and health risks.
  • To propose a comprehensive management strategy to mitigate the adverse effects of Profactor-H.

Main Methods:

  • Conceptual framework development for Profactor-H.
  • Analysis of contributing factors to Profactor-H.
  • Proposal of a four-pronged intervention program: dietary carbohydrate reduction, chromium supplementation, physical activity, and stress management.

Main Results:

  • Profactor-H disrupts metabolic balance, promoting anabolic metabolism and impaired insulin action, particularly in obese individuals.
  • A similar detrimental cycle is observed in non-obese individuals, predisposing them to future health issues.
  • The proposed intervention program is hypothesized to minimize Profactor-H's impact and reduce associated health risks.

Conclusions:

  • Profactor-H is a critical, unifying pathophysiological factor underlying a spectrum of chronic diseases.
  • A multi-faceted lifestyle intervention targeting carbohydrate intake, chromium levels, physical activity, and stress is recommended.
  • Implementing this program can lead to reduced health risks and improved overall health outcomes.

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