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Darwin's selection within the human body

J Zhao1

  • 1Department of Laboratory Medicine, Yale University School of Medicine, Yale-New Haven Hospital, CT 06520, USA.

Medical Hypotheses
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

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Evolutionary mechanisms, including natural selection, operate within multicellular organisms throughout their lifespan. This occurs due to cell individuality and somatic genetic variations, impacting both health and disease.

Area of Science:

  • Evolutionary Biology
  • Cellular Biology
  • Human Physiology

Background:

  • Darwin's natural selection is recognized for its role in diseases like cancer.
  • Its relevance to normal multicellular life has been historically disregarded.
  • This perspective overlooks potential evolutionary processes within the organism.

Purpose of the Study:

  • To propose that evolutionary mechanisms function throughout an organism's entire lifespan.
  • To investigate the role of cell individuality and somatic variations in this process.
  • To highlight the importance of understanding these mechanisms in biology and medicine.

Main Methods:

  • Conceptual hypothesis based on cell individuality.
  • Consideration of somatic genetic variations within cell populations.

Related Experiment Videos

  • Theoretical framework integrating evolutionary principles into multicellular life.

    • Main Results:

    • Natural selection and evolutionary mechanisms are hypothesized to be active in normal physiological conditions.
    • These processes are proposed to function from embryonic development through aging.
    • Cell individuality and somatic variations provide a basis for intra-organismal selection.

    Conclusions:

    • Evolutionary mechanisms are integral to multicellular life, not just disease.
    • Understanding these internal selection processes is crucial for advancing human biology and medicine.
    • This paradigm shift impacts our view of health, disease, and aging.