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Maxillary sinus marrow hyperplasia in sickle cell anemia

M Fernandez1, T L Slovis, W Whitten-Shurney

  • 1Department of Imaging, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201-2196, USA.

Pediatric Radiology
|November 1, 1995
PubMed

Insights

Sickle cell anemia (SCA) can cause marrow hyperplasia in children. This case highlights unusual maxillary sinus involvement in a young boy with SCA, offering key imaging insights for diagnosis.

Area of Science:

  • Hematology
  • Pediatric Radiology
  • Genetics

Background:

  • Sickle cell anemia (SCA) is a genetic blood disorder.
  • Marrow hyperplasia is a known complication of SCA, typically affecting the skull in children over five.
  • Facial bone involvement, excluding the mandible and orbits, is uncommon in SCA.

Observation:

  • A 28-month-old African American boy with SCA presented with unusual findings.
  • He exhibited extensive marrow hyperplasia of the maxillary sinuses.
  • Severe calvarial and mandibular changes were also noted.

Findings:

  • Computed Tomography (CT) revealed imaging characteristics consistent with marrow hyperplasia at other sites.
  • Magnetic Resonance (MR) imaging showed low signal intensity on both T1 and T2 sequences.
  • These imaging features are indicative of marrow hyperplasia in the maxillary sinuses.

Implications:

  • This case expands the understanding of marrow hyperplasia distribution in pediatric SCA.
  • Recognizing these imaging patterns can aid in the early and accurate diagnosis of SCA complications.
  • Further research into the specific mechanisms and prevalence of maxillary sinus involvement in SCA is warranted.

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