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Related Experiment Videos

Effect of amphetamine on human macronutrient intake

R W Foltin1, T H Kelly, M W Fischman

  • 1Division on Substance Abuse, New York State Psychiatric Institute, NY, USA.

Physiology & Behavior
|November 1, 1995
PubMed
Summary

Amphetamine (d-amphetamine) reduces overall caloric intake by decreasing eating frequency. Higher doses alter macronutrient selection, increasing carbohydrate

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Area of Science:

  • Nutritional Science
  • Pharmacology
  • Human Physiology

Background:

  • Amphetamine is known to affect appetite and food intake.
  • Understanding its impact on macronutrient selection is crucial for managing its side effects.

Purpose of the Study:

  • To investigate the effects of d-amphetamine on macronutrient intake in humans.
  • To determine if amphetamine influences the selection of carbohydrates, fats, and proteins.

Main Methods:

  • A 15-day residential study with six male subjects.
  • Manipulation of dietary carbohydrate content and administration of d-amphetamine (5, 10, or 30 mg/70 kg) or placebo.
  • Measurement of total caloric intake and macronutrient selection.

Main Results:

  • Both low and high doses of d-amphetamine decreased total caloric intake.
  • Lower doses did not affect macronutrient selection, but reduced eating bouts.
  • A high dose (30 mg) decreased intake of all macronutrients but increased the relative contribution of carbohydrates.

Conclusions:

  • D-amphetamine reduces caloric intake primarily by reducing the frequency of eating.
  • High doses of amphetamine can alter macronutrient selection, favoring carbohydrates.
  • These findings have implications for understanding drug-induced appetite changes.

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