Peripheral T-cell lymphomas in children

Approximately 20% of childhood non-Hodgkin's lymphomas (HNLs) are of peripheral T-cell type. These lymphomas form a heterogeneous group of neoplasms with different clinical features and responses to therapy. By far the most common among these lymphomas is the recently described Ki-1+ large cell lymphoma (LCL), but other types of peripheral T-cell lymphomas, which may rarely occur in children, include plemorphic T-cell lymphomas resembling adult T-cell leukemia/lymphoma (ATLL), angiocentric immunoproliferative lesions (AIL), angioimmunoblastic lymphadenopathy-like T-cell lymphoma, and cutaneous T-cell lymphoma (CTCL).