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Peripheral T-cell lymphomas in children

B A Agnarsson1, M E Kadin

  • 1Department of Pathology, University of Iceland, Reykjavik, Iceland.

Seminars in Diagnostic Pathology
|November 1, 1995
PubMed
Summary

Childhood non-Hodgkin's lymphomas (HNLs) include peripheral T-cell types, a diverse group of cancers. Ki-1+ large cell lymphoma (LCL) is the most frequent, but other rare types exist in children.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Immunopathology

Background:

  • Peripheral T-cell lymphomas constitute approximately 20% of childhood non-Hodgkin's lymphomas (HNLs).
  • These lymphomas represent a heterogeneous group of neoplasms with varied clinical presentations and therapeutic outcomes.
  • While Ki-1+ large cell lymphoma (LCL) is the most prevalent subtype, other rare peripheral T-cell lymphomas can occur in children.

Purpose of the Study:

  • To outline the spectrum of peripheral T-cell lymphomas in pediatric patients.
  • To highlight the heterogeneity within this group of childhood lymphomas.
  • To identify the most common and rare subtypes encountered in children.

Main Methods:

  • Review of existing literature on pediatric non-Hodgkin's lymphomas.
  • Classification of peripheral T-cell lymphomas based on morphological and immunophenotypic characteristics.
  • Analysis of clinical features and therapeutic responses associated with different subtypes.

Main Results:

  • Peripheral T-cell lymphomas are a significant subtype of childhood HNLs.
  • Ki-1+ large cell lymphoma (LCL) is the predominant type.
  • Other rare pediatric peripheral T-cell lymphomas include pleomorphic T-cell lymphomas (resembling ATLL), angiocentric immunoproliferative lesions (AIL), angioimmunoblastic lymphadenopathy-like T-cell lymphoma, and cutaneous T-cell lymphoma (CTCL).

Conclusions:

  • Pediatric peripheral T-cell lymphomas are diverse, requiring accurate subtyping for appropriate management.
  • Understanding the distinct characteristics of each subtype is crucial for optimizing treatment strategies in children.
  • Further research into rare T-cell lymphomas in children may improve diagnostic and therapeutic approaches.

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