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Related Experiment Videos

Diffuse esophageal spasm: a malfunction that involves nitric oxide?

J W Konturek1, A Gillessen, W Domschke

  • 1Dept. of Medicine B, University of Münster, Germany.

Scandinavian Journal of Gastroenterology
|November 1, 1995
PubMed
Summary

Nitric oxide (NO) influences esophageal motility timing. Glyceryl trinitrate (GTN) improved symptoms in diffuse esophageal spasm patients by prolonging latency and shortening contraction duration, suggesting NO pathway dysfunction.

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Area of Science:

  • Gastroenterology
  • Physiology
  • Pharmacology

Background:

  • Nitric oxide (NO) is implicated in regulating esophageal motility.
  • Dysregulation of NO may contribute to esophageal spasm.
  • Understanding NO's role is crucial for motility disorders.

Purpose of the Study:

  • To investigate the role of nitric oxide (NO) in esophageal motility.
  • To evaluate the effects of glyceryl trinitrate (GTN) and L-arginine on esophageal spasm.

Main Methods:

  • Esophageal manometry was performed on five patients with symptomatic diffuse esophageal spasm.
  • Intravenous glyceryl trinitrate (GTN) or L-arginine was administered.
  • Analysis included contraction amplitude, duration, propagation, and latency periods.

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Main Results:

  • GTN administration dose-dependently increased esophageal contraction latency and decreased duration.
  • GTN significantly alleviated dysphagia symptoms without adverse effects or blood pressure changes.
  • L-arginine did not alter motility patterns or improve symptoms.

Conclusions:

  • NO is vital for the timing of esophageal propulsive contractions.
  • GTN shows potential therapeutic benefit for symptomatic diffuse esophageal spasm.
  • Patients with diffuse esophageal spasm may have impaired endogenous NO synthesis or degradation.