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Increased intestinal permeability for the isosmolar contrast medium iodixanol during small-bowel ischaemia in rats
R Andersen1, A Stordahl, H Høyseth
1Institute for Surgical Research, Rikshospitalet, University of Oslo, Norway.
Background:
Intestinal ischaemia may be difficult to recognize in the early stages. Increased urinary recovery of water-soluble contrast medium during and intestinal follow-through has been suggested as a sign of bowel ischaemia.
Methods:
Urinary excretion of the isosmolar water-soluble X-ray contrast medium iodixanol was measured after instillation via an orogastric tube in 56 rats with occlusion of the mesenteric blood vessels.
Results:
Mesenteric venous occlusion caused only minor histologic alterations of the mucosa. High-performance liquid chromatography (HPLC) and X-ray fluorescence analysis measured urinary iodixanol concentrations 10 and 13 times higher than in the groups with mesenteric arterial occlusion than in controls (p < 0.001), and 3 and 4 times higher than in the group with venous occlusion (p < or = 0.05). Correlation between HPLC and X-ray fluorescence measurements of contrast medium in urine was strong (r = 0.98).
Conclusion:
Measuring urinary contrast medium levels during intestinal follow-through may aid in distinguishing bowel ischaemia following mesenteric arterial occlusion from mesenteric venous occlusion and from the normal bowel.