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The pH/PCO2 method for continuous determination of human gastric acid and bicarbonate secretion. A validation study
J Dalenbäck1, L Fändriks, L Olbe
1Dept. of Surgery, Sahlgrenska University Hospital, Göteborg University, Sweden.
Scandinavian Journal of Gastroenterology
|September 1, 1995
Summary
This study introduces a pH/PCO2 technique for accurately measuring gastric acid and bicarbonate output in real-time. The method is well-suited for studying stomach secretion and motility interactions.
Area of Science:
- Gastroenterology
- Physiology
- Medical Technology
Background:
- Investigating rapid, interdigestive changes in gastric acid and bicarbonate secretion.
- Evaluating a novel methodologic approach for real-time registration of these changes.
Purpose of the Study:
- To describe and evaluate a pH/PCO2 technique for measuring gastric acid and bicarbonate outputs.
- To assess the time resolution and accuracy of the technique in healthy volunteers.
Main Methods:
- Utilizing continuous gastric luminal perfusion with pH and PCO2 measurements.
- Employing concomitant intragastric/duodenal manometry.
- Recruiting fourteen healthy volunteers for the study.
Main Results:
- Acid secretory estimations closely correlated with conventional titration.
- Bicarbonate recovery was near-instantaneous at neutral pH but lower in the acid range (53%).
- High gastric perfusion rates improved bicarbonate recovery in acidic conditions.
Conclusions:
- The pH/PCO2 technique offers near real-time assessment of gastric acid and bicarbonate.
- Accurate acid measurement is achievable, but bicarbonate may be underestimated in acidic conditions.
- High perfusion rates enhance accuracy, making the technique suitable for studying gastric secretion and motility.