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Growth factors: new 'endogenous drugs' for ulcer healing

S Szabo1, S Kusstatscher, G Sakoulas

  • 1Dept. of Pathology, University of California, Irvine, USA.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1995
PubMed
Abstract

Insights

Growth factors like basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) accelerate ulcer healing. These factors offer a direct therapeutic approach for gastroduodenal ulcers, independent of acid suppression.

Area of Science:

  • Gastroenterology
  • Regenerative Medicine
  • Pharmacology

Background:

  • Gastroduodenal ulcer pathogenesis traditionally focused on aggressive factors, with therapies indirectly influencing healing.
  • The discovery of growth factors enables direct ulcer treatment, bypassing the need to inhibit gastric acid and pepsin.
  • This review examines recent data on growth factor efficacy in promoting ulcer healing.

Purpose of the Study:

  • To review recent data on the efficacy of growth factors in promoting ulcer healing.
  • To compare the effects of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) with epidermal growth factor (EGF).

Main Methods:

  • Experimental induction of chronic duodenal and gastric ulcers in rats.
  • Administration of bFGF and PDGF to assess their effects on ulcer healing.
  • Evaluation of additive or synergistic effects with cimetidine or sucralfate.

Main Results:

  • bFGF and PDGF significantly accelerated the healing of experimental chronic duodenal and gastric ulcers in rats.
  • Ulcer healing occurred without suppression of gastric acid secretion, resulting in superior tissue quality.
  • Additive or synergistic effects were observed between bFGF and cimetidine or sucralfate in specific ulcer models.

Conclusions:

  • Growth factors, including bFGF and PDGF, can effectively promote gastroduodenal ulcer healing.
  • Direct therapeutic strategies utilizing growth factors are viable, independent of gastric acid neutralization.
  • These findings suggest a potential for direct and efficient therapeutic regimens for ulcer management.

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