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Related Experiment Videos

Primary nocturnal enuresis: a urodynamic study spanning three generations

B R Birch1, R A Miller

  • 1Southampton University Hospitals, England.

Scandinavian Journal of Urology and Nephrology
|September 1, 1995
PubMed
Summary

Primary nocturnal enuresis has a genetic link. This study found evidence that detrusor instability, a common feature, may be inherited as an autosomal dominant trait.

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Area of Science:

  • Urology
  • Genetics
  • Pediatrics

Background:

  • Familial incidence of primary nocturnal enuresis (PNE) is recognized.
  • Twin studies indicate a significant genetic component in PNE etiology.
  • Previous family studies relied solely on symptomatic inquiry, overlooking detrusor instability in 70-80% of PNE cases.

Purpose of the Study:

  • To investigate the familial transmission pattern of detrusor instability in primary nocturnal enuresis.
  • To provide the first description of a family with urodynamically proven detrusor instability across three generations.

Main Methods:

  • Urodynamic assessment of adult family members across three generations.
  • Analysis of the inheritance pattern of detrusor instability within the family.

Main Results:

  • Urodynamically proven detrusor instability was identified in adult family members spanning three generations.
  • The observed pattern of inheritance supports a genetic basis for detrusor instability.

Conclusions:

  • Detrusor instability associated with primary nocturnal enuresis may be transmitted as an autosomal dominant characteristic.
  • This finding supports a strong genetic etiology for detrusor instability in PNE.

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