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Related Experiment Videos

Nucleus pulposus pulmonary embolism. A case report

R I Schreck1, W L Manion, P Kambin

  • 1Department of Pathology, Graduate Hospital, Philadelphia, Pennsylvania, USA.

Spine
|November 15, 1995
PubMed
Summary

This case report details the first human instance of nucleus pulposus pulmonary embolism following a discography procedure. The study highlights potential risks associated with spinal interventions and contrast materials.

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Area of Science:

  • Forensic pathology
  • Radiology
  • Cardiopulmonary medicine

Background:

  • The intervertebral disc's nucleus pulposus has been implicated in embolisms to spinal vessels and, in animal models, to the lungs.
  • This study addresses the first documented case of nucleus pulposus pulmonary embolism in a human patient.

Observation:

  • A patient undergoing lumbar discography for low back pain experienced a fatal systemic reaction.
  • Postmortem examination revealed nucleus pulposus pulmonary emboli and herniated disc material within vertebral marrow spaces.

Findings:

  • Microscopic analysis confirmed nucleus pulposus emboli in lung tissue.
  • Vertebral herniations indicated extrusion of disc material into marrow spaces.

Implications:

Related Experiment Videos

  • The findings suggest that forceful back extensions during procedures may cause nucleus pulposus extrusion, leading to pulmonary embolism.
  • This case underscores the importance of caution with intrathecal contrast material during radiologic procedures to prevent adverse events.