Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conformational changes in adhesive proteins modulate their adhesive function

T Ugarova1, F R Agbanyo, E F Plow

  • 1Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA.

Thrombosis and Haemostasis
|July 1, 1995
PubMed
Summary

Cell adhesion is regulated by large glycoproteins that change shape. Conformational changes in proteins like thrombospondin, fibrinogen, and fibronectin control their binding to cell receptors, influencing cell adhesion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The plasma carboxypeptidases and the regulation of the plasminogen system.

Trends in cardiovascular medicine·2011
Same author

Phosphatidylserine as an anchor for plasminogen and its plasminogen receptor, histone H2B, to the macrophage surface.

Journal of thrombosis and haemostasis : JTH·2010
Same author

Platelet integrin alpha(IIb)beta(3): activation mechanisms.

Journal of thrombosis and haemostasis : JTH·2007
Same author

Vitronectin: back into the spotlight.

Journal of thrombosis and haemostasis : JTH·2005
Same author

A central role for plasminogen in the inflammatory response to biomaterials.

Journal of thrombosis and haemostasis : JTH·2004
Same author

Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.

Journal of medical genetics·2004

Area of Science:

  • Biochemistry
  • Cell Biology
  • Structural Biology

Background:

  • Cell adhesion is crucial for multicellular organisms, mediated by adhesive proteins binding to cellular receptors.
  • Adhesive proteins are typically large, multi-domain molecules with self-association capabilities.
  • These proteins exhibit susceptibility to structural modulation, a key feature for regulating their function.

Purpose of the Study:

  • To elucidate the role of conformational changes in regulating the adhesive functions of glycoproteins.
  • To demonstrate how structural modulation impacts the adhesive potential of specific proteins.

Main Methods:

  • Analysis of the structural properties of adhesive glycoproteins.
  • Investigation of conformational alterations in thrombospondin, fibrinogen, and fibronectin.

Related Experiment Videos

  • Assessment of how these conformational changes affect protein-ligand interactions.

    • Main Results:

    • Adhesive glycoproteins possess a general susceptibility to structural modulation.
    • Conformational changes were observed in thrombospondin, fibrinogen, and fibronectin.
    • These alterations directly modulated the adhesive potential of the studied proteins.

    Conclusions:

    • The conformational status of adhesive glycoproteins is a critical determinant of their adhesive functions.
    • Structural modulation provides a regulatory mechanism for cell adhesion.
    • Understanding these conformational dynamics is key to comprehending cell-cell interactions.