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Updated: Aug 7, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Resistance to activated protein C and factor V Leiden as risk factors for venous thrombosis
R M Bertina1, P H Reitsma, F R Rosendaal
1Hemostasis and Thrombosis Research Center, University Hospital Leiden, The Netherlands.
Abstract:
The recent discovery of the factor V Leiden mutation as the molecular defect in the large majority of APC-resistant individuals, has drastically changed our view on familial thrombophilia and it has contributed to a better understanding of the interaction of genetic and environmental risk factors. It has offered firm support for the view that venous thrombosis is a multifactorial disease and that the risk of thrombosis will increase as the number of genetic and/or environmental risk factors increases.
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