Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quality control and oral anticoagulation

F E Preston1

  • 1Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK.

Thrombosis and Haemostasis
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guidelines on the diagnosis and management of chronic liver disease in haemophilia.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Development of a World Federation of Hemophilia External Quality Assessment Scheme: results of a pilot study.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Stability of coagulation proteins in lyophilized plasma.

International journal of laboratory hematology·2014
Same author

Importance of Night-vision Tests.

British medical journal·2010
Same author

Quality issues in laboratory haemostasis.

Haemophilia : the official journal of the World Federation of Hemophilia·2010
Same author

Mass in Vitreous in a Boy aged 5, ? Glioma.

Proceedings of the Royal Society of Medicine·2009
Same journal

Discontinuation of Oral Anticoagulation After Successful Catheter Ablation for Atrial Fibrillation: Meta-analysis of Randomized Clinical Trials.

Thrombosis and haemostasis·2026
Same journal

Novel/Recurrent Variants in Pakistani Glanzmann Thrombasthenia and Glanzmann-like bleeding diathesis: Insights from NGS Analysis.

Thrombosis and haemostasis·2026
Same journal

Anti-TFPI Single-Domain Antibodies: Novel Rebalancing Therapies for Hemophilia and Other Rare Bleeding Disorders.

Thrombosis and haemostasis·2026
Same journal

The Interaction of Fibrin with Endothelial Cell Receptor N-Cadherin Promotes Fibrin-Dependent Angiogenesis.

Thrombosis and haemostasis·2026
Same journal

Antiphospholipid Antibodies and Atrial Fibrillation: Clinical Implications and the TaPL AF Study Design.

Thrombosis and haemostasis·2026
Same journal

Prasugrel vs. Ticagrelor: Can TUXEDO-2 Settle the Debate?

Thrombosis and haemostasis·2026
See all related articles

The International Normalized Ratio (INR) system enhances oral anticoagulant control, patient safety, and therapeutic efficacy. Careful management of variables like thromboplastin choice and quality assessment is crucial for its success.

Area of Science:

  • Clinical Pathology
  • Hematology
  • Medical Laboratory Science

Background:

  • The International Normalized Ratio (INR) system significantly improved oral anticoagulant monitoring, enhancing both therapeutic efficacy and patient safety.
  • The reliability of the INR system depends on meticulous control over critical variables.

Purpose of the Study:

  • To highlight the importance of key variables in the INR system for effective oral anticoagulant monitoring.
  • To emphasize the role of external quality assessment schemes in identifying and resolving laboratory practice issues.

Main Methods:

  • Analysis of variables influencing INR system accuracy, including thromboplastin selection, International Sensitivity Index (ISI) assignment, mean normal prothrombin time determination, and end-point detection.
  • Utilizing participation in independent external quality assessment schemes for laboratory performance analysis.

Related Experiment Videos

Main Results:

  • External quality assessment schemes identify laboratory-specific practice problems and highlight issues with reagents and coagulometers.
  • Identified problems with ISI assignment for thromboplastins used with coagulometers, stimulating the development of local ISI determination calibrants.

Conclusions:

  • The INR system's success hinges on rigorous attention to critical variables and robust quality control measures.
  • External quality assessment is vital for maintaining the accuracy and reliability of INR monitoring and identifying suboptimal reagents or equipment.