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The normalization period of platelet aggregation in newborns
S Tanindi1, A E Kürekçi, V Köseoğlu
1Department of Pediatrics, Gülhane Military Medical Academy, Ankara, Turkey.
Thrombosis Research
|October 1, 1995
Summary
Newborns exhibit transient platelet dysfunction that normalizes within 5-9 days. This study tracked platelet aggregation, finding responses to collagen and ADP improve with age, reaching adult levels by the second week of life.
Area of Science:
- Neonatal Physiology
- Hematology
- Pediatric Thrombosis
Background:
- Neonatal platelet dysfunction is a recognized phenomenon.
- Understanding its duration is crucial for clinical management.
- Previous studies have yielded varied results on normalization timelines.
Purpose of the Study:
- To determine the normalization period of transient platelet dysfunction in healthy newborns.
- To compare platelet aggregation responses in newborns and adults.
- To identify the age at which neonatal platelet function reaches adult levels.
Main Methods:
- Investigated platelet aggregation in 43 healthy newborns and 44 healthy adults.
- Utilized whole blood impedance aggregometry.
- Employed collagen and adenosine diphosphate (ADP) as aggregating agents.
Main Results:
- Newborns showed significantly lower maximum platelet aggregation with collagen in the first three days of life compared to adults (p < 0.001).
- Platelet aggregation values in newborns reached adult levels between the 5th and 9th day of life.
- Responses to ADP were similar, with no significant difference except at a 5 microM concentration.
Conclusions:
- Neonatal platelet function, particularly in response to collagen and ADP, matures and normalizes between the 5th and 9th day of life.
- Persistent platelet dysfunction beyond 10 days may indicate prolonged physiological effects or underlying platelet disorders.
- This study provides a clear timeframe for the resolution of transient neonatal platelet dysfunction.