Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiological changes in serum erythropoiesis stimulating activity

J A Napier, C D Dunn, T W Ford

    British Journal of Haematology
    |March 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patients cared for in the Corridor of a large hospital in the United Kingdom: Sick, elderly, and sad.

    Acute medicine·2025
    Same author

    Society for Acute Medicine undergraduate syllabus for Acute Internal Medicine.

    Acute medicine·2024
    Same author

    Fat mass, weight and body shape changes at menopause - causes and consequences: a narrative review.

    Climacteric : the journal of the International Menopause Society·2023
    Same author

    Developing priorities for quality improvement in acute medicine using a modified Delphi method A consensus process hosted by the Society for Acute Medicine Quality Improvement Committee (SAM-QI).

    Acute medicine·2022
    Same author

    Quality: What does it mean in Acute Medicine and how do we measure it?

    Acute medicine·2021
    Same author

    Genetically modified plants are an alternative to oily fish for providing <i>n</i>-3 polyunsaturated fatty acids in the human diet: A summary of the findings of a Biotechnology and Biological Sciences Research Council funded project.

    Nutrition bulletin·2021

    The mouse fetal liver cell bioassay quantifies erythropoiesis stimulating activity (ESA) in patients. This assay confirms ESA

    Area of Science:

    • Hematology
    • Biotechnology
    • Assay Development

    Background:

    • Serum erythropoiesis stimulating activity (ESA) is crucial for red blood cell production.
    • Understanding ESA levels is important in various hematological disorders.
    • Existing methods for ESA measurement have limitations.

    Purpose of the Study:

    • To validate the mouse fetal liver cell bioassay for quantitative measurement of serum ESA.
    • To assess the correlation of ESA levels with erythropoiesis regulation in vivo.
    • To compare the assay's performance with established erythropoietin standards.

    Main Methods:

    • Utilized a mouse fetal liver cell bioassay.
    • Measured serum ESA levels in patients with hematological disturbances.

    Related Experiment Videos

  • Generated dose-response curves for comparison with reference standards.

    • Main Results:

    • The bioassay provides a quantitative measurement of serum ESA.
    • ESA concentrations varied predictably, supporting its role in erythropoiesis regulation.
    • Significant parallelism was observed between serum ESA dose-response curves and erythropoietin standards.

    Conclusions:

    • The mouse fetal liver cell bioassay is a reliable method for quantifying serum ESA.
    • This assay system effectively reflects the in vivo regulatory function of ESA in erythropoiesis.
    • The assay demonstrates consistency with international standards for erythropoietin.