Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fos and bone cell development: lessons from a nuclear oncogene

A E Grigoriadis, Z Q Wang, E F Wagner

    Trends in Genetics : TIG
    |November 1, 1995
    PubMed
    Summary

    The proto-oncogene Fos plays a key role in regulating bone and cartilage cell development. Understanding Fos is crucial for insights into skeletal development and bone diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    C-phycocyanin to overcome the multidrug resistance phenotype in human erythroleukemias with or without interaction with ABC transporters.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2018
    Same author

    The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment.

    Leukemia·2016
    Same author

    Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

    Cell death & disease·2016
    Same author

    Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1.

    Oncogene·2016
    Same author

    Association between serum angiopoietin-2 concentration and clinicopathological parameters in patients with colorectal cancer.

    Genetics and molecular research : GMR·2015
    Same author

    The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.

    Cell death and differentiation·2015

    Area of Science:

    • Skeletal biology and developmental biology.

    Background:

    • Vertebrate skeletal element development and patterning are increasingly understood.
    • Regulators of bone and cartilage cell differentiation remain poorly defined.

    Purpose of the Study:

    • To investigate the role of the proto-oncogene Fos in skeletal cell development and activity.

    Main Methods:

    • Utilized transgenic and knockout mouse models.
    • Examined the function of Fos in bone cell populations.

    Main Results:

    • Established a unique role for Fos in regulating specific bone cell populations.
    • Demonstrated Fos's involvement in both normal skeletal development and bone disease.

    Conclusions:

    • Fos is a significant regulator of bone cell differentiation and activity.
    • Further research into Fos may illuminate mechanisms underlying skeletal development and disease.

    Related Experiment Videos