Cardiovascular, respiratory and metabolic effects of interval training at VLA4

The purpose of this study was to determine if training with short intervals at the velocity producing a lactate level of 4 mmol/l (VLA4) is sufficient to induce adaptations and better exercise tolerance. Five Standardbred mares (4-8 years) were interval trained on a treadmill 3 days a week for 12 weeks and subsequently detrained for 4 weeks. Standardized exercise tests were performed before, during and after the training period and muscle biopsies were taken. Measurements were made of heart rate, oxygen consumption, stride frequency, blood volume and blood lactate. Plasma volume was reduced after 2 weeks of training but then increased to the approximate pre-training value throughout the remaining training and post-training periods. No change was detected in the total cell volume whereas the total blood volume varied in consequence with the plasma volume variation. A significant reduction in heart rate response to exercise was seen after 4 weeks of training. VLA4 increased after 2 weeks of training and remained higher than the baseline value during the rest of the training period. Consequently, the blood lactate at 8 m/sec was decreased compared to baseline concentration after 8 and 12 weeks of training. The post-training VLA4 did not differ significantly either from the end of training or from the pre-training value. Mass specific oxygen consumption (VO2-200/BW) at V200 increased with training and decreased with detraining. The respiratory quotient at a velocity of 8 m/sec decreased from 1.18 +/- 0.02 before training to 1.07 +/- 0.02 (P < 0.05) at the end of training. No changes were found in muscle histo- or biochemical parameters. The results indicate that training at VLA4 is sufficient to cause adaptational changes in exercise tolerance related parameters.