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Lipoprotein (a): effect of detraining

G Cerioli1, F Tirelli, A Bonetti

  • 1Chair of Sports Medicine, University of Parma.

Acta Bio-Medica De L'Ateneo Parmense : Organo Della Societa Di Medicina E Scienze Naturali Di Parma
|January 1, 1995
PubMed
Summary

Long-distance running temporarily alters blood lipid profiles. Lipoprotein (a) levels significantly increased after a month of detraining following marathon exertion.

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Biochemistry
  • Lipid Metabolism

Background:

  • Lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease.
  • Endurance exercise can influence various lipid parameters.
  • The specific impact of marathon running on Lp(a) and other lipids requires further investigation.

Purpose of the Study:

  • To investigate the effects of marathon running on plasma levels of lipoprotein (a) and other key lipid parameters.
  • To assess the recovery of these parameters after a period of detraining.

Main Methods:

  • Blood samples were collected from 8 long-distance runners before and immediately after the New York Marathon.
  • Lipid profiles, including Lp(a), total cholesterol, triglycerides, HDL-C, LDL-C, apo-A1, and apo-B, were analyzed.
  • Samples were also taken after one month of detraining to evaluate recovery.

Main Results:

  • Lipoprotein (a) levels significantly increased after detraining compared to both pre-race and post-race values.
  • Other evaluated metabolic parameters showed negligible and predictable modifications.
  • No significant correlation was found between Lp(a) levels and anthropometrical or metabolic data.

Conclusions:

  • Marathon running does not significantly alter most routine lipid parameters in the short term.
  • A month of detraining leads to a significant elevation in lipoprotein (a) levels.
  • Further research is needed to understand the long-term implications of these Lp(a) changes in athletes.

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