Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adenosine deaminase in progressive systemic sclerosis

P Meunier1, P Filipe, I Emerit

  • 1Institute Biomédical des Cordeliers, University Paris VI, France.

Acta Dermato-Venereologica
|July 1, 1995
PubMed
Summary

Adenosine deaminase (ADA) activity is elevated in patients with progressive systemic sclerosis (PSS), even in early stages. This enzyme

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Midazolam prescription as a trigger for potential deceased donor identification outside the ICU: a prospective feasibility study.

BMC palliative care·2026
Same author

Clinical Complete Response and Organ Preservation Strategies in Rectal Cancer: A Real-World Single-Center Experience Clinical Complete Response and Organ Preservation in Rectal Cancer.

Cancers·2026
Same author

Incidence and Survival of IDH-Wildtype Glioblastoma and IDH-Mutant Astrocytoma by Treatment and Sex: A Regional Study in Spain (2011-2021).

Medical sciences (Basel, Switzerland)·2025
Same author

Probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids syndrome: management with corticosteroids and intravenous immunoglobulin-a case report.

Journal of medical case reports·2025
Same author

Real-World Evidence on the Effectiveness and Safety of Spesolimab in the Treatment of Generalized Pustular Psoriasis Flares: A Case Series.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2025
Same author

Subungual Exostosis of the Second Finger.

Actas dermo-sifiliograficas·2024

Area of Science:

  • Immunology
  • Rheumatology
  • Biochemistry

Background:

  • Progressive systemic sclerosis (PSS) is a complex autoimmune disease.
  • Previous research suggested elevated adenosine deaminase (ADA) activity in PSS.
  • The role of ADA as a marker of T-cell activation is established.

Purpose of the Study:

  • To confirm increased adenosine deaminase (ADA) activity in progressive systemic sclerosis (PSS).
  • To compare plasma ADA activity across different stages of PSS.
  • To investigate ADA as a potential indicator of disease activity in PSS.

Main Methods:

  • A cohort of 48 PSS patients was analyzed.
  • Patients were classified into three subgroups based on disease extent (skin-limited, skin/oesophagus, multi-organ involvement).

Related Experiment Videos

  • Plasma ADA activity was quantified using a colorimetric assay.

    • Main Results:

    • Adenosine deaminase (ADA) activity was significantly increased in PSS patients compared to controls.
    • ADA levels were highest in patients with multi-organ involvement (subgroup 3).
    • Elevated ADA levels were observed even in the early, skin-limited stage of PSS (subgroup 1).

    Conclusions:

    • The study confirms elevated ADA activity in progressive systemic sclerosis (PSS).
    • Increased ADA is present from the early stages of PSS.
    • Elevated ADA may serve as a marker for disease activity in PSS, including during exacerbations.