[Morphologic diagnosis of insulinoma]

Insulinoma diagnosis may be sometimes very difficult. Insulinomas and extra-tumor pancreatic tissue from 31 patients underwent combined macro- and microscopical investigation in order to find morphological changes important for the diagnosis. The silver impregnation of pancreatic islands according to Grimelius appeared to be most informative. Negative reaction in Langerhans islands shows the presence of insulinoma; positive Grimelius reaction makes the diagnosis of insulinoma doubtful.