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[Allogeneic transplantation and HIV infection: studies of HIV-infected tissue]
J Bujía1, E Kastenbauer, E Wilmes
1Klinik und Poliklinik für Hals-Nasen- und Ohrenkranke.
Background:
Because of the limited availability of autologous tissue, stored allograft is commonly used. Before grafting, bank tissue is subjected to chemical preservation procedures. This procedure is important to diminish antigenicity and to inactivate possible inherent viruses. The aim of this study was to determine the influence of different chemical preservation procedures like Cialit, Merthiolate, and formaldehyde on the presence of HIV DNA.
Methods:
HIV-infected tissues were obtained from eight HIV-positive patients and examined using the polymerase chain reaction (PCR).
Results:
After chemical treatment, we could observe the presence of HIV DNA in all examined tissues.
Conclusions:
The findings indicate the importance of the mandatory serological screening and selection in donor patients.