Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Strategies for evaluating carcinogenic substances]

D Henschler1

  • 1Institut für Toxikologie, Universität Würzburg.

Zentralblatt Fur Hygiene Und Umweltmedizin = International Journal of Hygiene and Environmental Medicine
|April 1, 1995
PubMed
Summary

Chemicals causing cancer have been known for centuries. New technical guidance values (TRKs) aim to protect workers by accepting a residual cancer risk, a concept differing from traditional MAK-values.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of metabolic activation in the toxicity of S-(pentachlorobutadienyl)glutathione and S- (pentachlorobutadienyl)- l -cysteine in the isolated perfused rat kidney.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

The inhibitory effect of neuropathic organophosphate esters on neurite outgrowth in cell cultures: A basis for screening for delayed neurotoxicity.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Genotoxicity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

The origin of hormesis: historical background and driving forces.

Human & experimental toxicology·2006
Same author

Renal cell cancer correlated with occupational exposure to trichloroethene.

Journal of cancer research and clinical oncology·2000
Same author

Isocyanate-specific hemoglobin adduct in rats exposed to 4, 4'-methylenediphenyl diisocyanate.

Chemical research in toxicology·2000

Area of Science:

  • Toxicology
  • Occupational Health

Context:

  • Chemical carcinogens have been recognized for over 200 years.
  • Approximately 40 human carcinogens and over 300 animal carcinogens are identified.
  • Existing classification systems categorize carcinogens (A1, A2) and suspect agents.

Purpose:

  • To introduce and explain technical guidance values (TRKs) for managing occupational exposure to carcinogens.
  • To differentiate TRKs from MAK-values by incorporating residual cancer risk.
  • To discuss the concept of acceptable residual risk and its political consensus.

Summary:

  • No safe threshold exists for known carcinogens.
  • TRKs acknowledge a residual cancer risk, which is often unquantifiable.
  • The acceptable level of residual risk requires societal consensus.
  • Unit risks are discussed for quantitative comparisons.

Impact:

  • Improves worker protection against chemical carcinogens.
  • Provides a framework for managing unavoidable cancer risks in the workplace.
  • Highlights the need for political and societal agreement on acceptable risk levels.

Related Experiment Videos