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[Oligohidrosis caused by zonisamide]

A Okumura1, F Hayakawa, K Kuno

  • 1Department of Pediatrics, Anjo Kosei Hospital, Aichi.

No to Hattatsu = Brain and Development
|January 1, 1996
PubMed
Summary

Zonisamide (ZNS) is linked to reduced sweating (oligohidrosis) in patients. Discontinuing ZNS improved sweat responses, suggesting ZNS can cause sweat gland dysfunction.

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Area of Science:

  • Neurology
  • Dermatology
  • Pharmacology

Background:

  • Oligohidrosis, or reduced sweating, is a potential side effect of certain medications.
  • Zonisamide (ZNS) is an anticonvulsant medication with various therapeutic uses.

Purpose of the Study:

  • To investigate the relationship between zonisamide (ZNS) use and the occurrence of oligohidrosis.
  • To determine if ZNS directly impacts sweat gland function.

Main Methods:

  • Retrospective review of 70 patients treated with zonisamide (ZNS).
  • Patient interviews to identify cases of oligohidrosis.
  • Physiological testing including heat loading and acetylcholine (Ach) loading tests for sweat response evaluation.
  • Assessment of sweat response changes after ZNS discontinuation.

Main Results:

  • Twelve out of 70 patients exhibited oligohidrosis.
  • All six patients tested with heat loading showed decreased sweat response.
  • All five patients tested with acetylcholine loading demonstrated reduced sweat response.
  • Two patients experienced recovery of sweat function after discontinuing ZNS.

Conclusions:

  • Zonisamide (ZNS) is associated with the development of oligohidrosis.
  • ZNS appears to cause dysfunction of the sweat glands.
  • Further research is warranted to understand the mechanism of ZNS-induced anhidrosis.

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