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Evolution of the pathogenesis of postmenopausal bone loss
1Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756, USA.
Bone
|October 1, 1995
Summary
This review explores the evolving understanding of postmenopausal osteoporosis causes, from early hypoosteoblastic theories to current concepts involving hormonal, cellular, and mechanical factors.
Area of Science:
- Bone biology and disease
- Endocrinology
- Gerontology
Background:
- Postmenopausal osteoporosis is a significant health concern.
- Understanding its etiology is crucial for effective treatment.
Purpose of the Study:
- To review the historical and current hypotheses on the pathogenesis of postmenopausal osteoporosis.
- To provide a comprehensive overview of the evolving scientific understanding.
Main Methods:
- Literature review of key hypotheses and theories.
- Historical analysis of scientific thought on osteoporosis etiology.
Main Results:
- Traces the evolution of thought from Albright's hypoosteoblastic hypothesis.
- Includes hypotheses on osteoclasia, calcium balance, and hormonal regulation.
- Incorporates newer concepts like growth factors, cytokines, and mechanical set points.
Conclusions:
- The understanding of postmenopausal osteoporosis pathogenesis has significantly evolved.
- Multiple factors, including cellular, hormonal, and mechanical, contribute to the disease.