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[Intravenous anesthesia--current aspects]

S Schraag1, M Georgieff

  • 1Klinik für Anästhesiologie, Universität Ulm.

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|December 1, 1995
PubMed
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Continuous intravenous anaesthesia is advancing with new drugs like remifentanil and improved delivery systems. Understanding pharmacokinetics and pharmacodynamics, including context-sensitive half-times, is key to its wider adoption.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Clinical Practice

Background:

  • Intravenous anaesthesia is gaining popularity due to new drugs and systems.
  • Widespread clinical adoption is limited by a lack of understanding of its scientific basis.
  • This review addresses recent advancements in intravenous anaesthetic pharmacology and delivery.

Purpose of the Study:

  • To review recent findings and developments in intravenous anaesthesia.
  • To cover pharmacology, pharmacokinetics, pharmacodynamics, and application systems.
  • To introduce concepts like context-sensitive half-times and effect-site equilibration.

Main Methods:

  • Review of current literature on intravenous anaesthetic drugs and systems.
  • Discussion of pharmacokinetic and pharmacodynamic principles.

Related Experiment Videos

  • Description of new drugs (remifentanil) and drug properties (propofol).
  • Overview of target-controlled infusion systems and modern pumps.

    • Main Results:

    • New opioid remifentanil is discussed.
    • Context-sensitive half-times are introduced for estimating drug effect decrease.
    • Pharmacodynamic properties can be characterized using effect-site equilibration time and Cp50.
    • Target-controlled infusion systems enable rapid achievement and maintenance of stable drug concentrations.
    • Propofol exhibits beneficial properties like antiemetic and antioxidant effects.

    Conclusions:

    • Understanding pharmacokinetics and pharmacodynamics is crucial for effective intravenous anaesthesia.
    • Target-controlled infusion systems and advanced pumps facilitate precise drug delivery.
    • Further dissemination of scientific knowledge is needed for broader clinical application.