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Treatment-resistant depression in the elderly

D Bonner1, R Howard

  • 1Maudsley Hospital, London, England, UK.

International Psychogeriatrics
|January 1, 1995
PubMed
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Treatment-resistant depression (TRD) in the elderly presents challenges. Careful, vigorous treatment may reveal true nonresponse is rarer than the estimated 18% to 40% prevalence.

Area of Science:

  • Geriatric psychiatry
  • Mental health research
  • Clinical psychology

Background:

  • Apparent treatment-resistant depression (TRD) is a significant clinical challenge in elderly patients.
  • Prevalence estimates for true nonresponse to depression treatment in the elderly range from 18% to 40%.

Purpose of the Study:

  • To review the concept of TRD in the elderly population.
  • To discuss factors contributing to apparent treatment resistance.
  • To explore effective treatment strategies for this demographic.

Main Methods:

  • Literature review on TRD in the elderly.
  • Analysis of factors influencing treatment response.
  • Synthesis of current treatment approaches.

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Main Results:

  • Apparent TRD is common, posing diagnostic and therapeutic difficulties for geriatric psychiatrists.
  • Accurate prevalence of true nonresponse is uncertain, with estimates varying widely.
  • Careful and vigorous treatment protocols may reduce the incidence of apparent TRD.

Conclusions:

  • True treatment-resistant depression in the elderly might be less common than previously estimated.
  • Thorough and assertive treatment strategies are crucial for optimizing outcomes.
  • Further research is needed to precisely define and manage TRD in older adults.