Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Amyotrophic lateral sclerosis

¹Neuromuscular Diseases Unit, Vancouver General Hospital, Canada.

Internal Medicine (Tokyo, Japan)

|September 1, 1995

Summary

Amyotrophic lateral sclerosis (ALS) involves complex mechanisms like excitotoxicity and free radicals, leading to neurological deficits. Current therapies focus on neuroprotection and symptom management targeting the disease's final stages.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2022

Same author

Breast cancer diagnosis and treatment wait times in specialized diagnostic units compared with usual care: a population-based study.

Current oncology (Toronto, Ont.)·2020

Same author

Baseline staging imaging for distant metastasis in women with stages I, II, and III breast cancer.

Current oncology (Toronto, Ont.)·2020

Same author

Cost-utility analysis of 21-gene assay for node-positive early breast cancer.

Current oncology (Toronto, Ont.)·2019

Same author

Impact of a novel prioritization framework on clinician-led oncology drug submissions.

Current oncology (Toronto, Ont.)·2019

Same author

Response to: The Survival Time of 8376 Male Breast Cancer Patients.

Clinical oncology (Royal College of Radiologists (Great Britain))·2018

Area of Science:

Neuroscience
Neurology
Molecular Biology

Background:

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
The final cascade of ALS correlates with clinical neurological deficits.
Multifactorial interactive mechanisms drive the terminal events of ALS.

Purpose of the Study:

To elucidate the mechanisms underlying the final cascade of ALS.
To identify the selective vulnerability of the corticomotneuronal system in ALS.
To outline therapeutic strategies targeting the final cascade of ALS.

Main Methods:

Analysis of multifactorial interactive mechanisms in ALS.
Investigation of excitotoxicity, free radical accumulation, and immunological disturbances.
Examination of gene product degradation in the corticomotneuronal system.

Main Results:

The final cascade of ALS involves excitotoxicity, free radical accumulation, and potential immunological disturbances.
Selective vulnerability of the corticomotneuronal system is linked to degradation of specific gene products.
Unidentified triggers likely precede the final cascade by months or years.

Conclusions:

Therapeutic strategies for ALS should target the final cascade.
Neuroprotection, symptomatic, and combination neuronal therapies are key.
Understanding the underlying mechanisms is crucial for effective ALS treatment.

Related Experiment Videos