Related Experiment Video
Updated: Aug 2, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Herpes simplex virus type 2 infections presenting as brainstem encephalitis and recurrent myelitis
H Nakajima1, D Furutama, F Kimura
1First Department of Internal Medicine, Osaka Medical College.
Abstract:
We describe here 3 patients with central nervous system infection caused by herpes simplex virus type 2 (HSV-2); one patient with brainstem encephalitis and two with recurrent transverse thoracic myelitis. All three patients showed increased IgG antibodies to HSV in the cerebrospinal fluid (CSF). HSV-2 DNA was demonstrated in the CSF by polymerase chain reaction (PCR) amplification. Upon treatment with acyclovir, one patient with myelitis partially recovered and the others completely recovered. It is important to recognize the wide spectrum of clinical manifestations of HSV-2 infection in the central nervous system (CNS).
Related Concept Videos
Herpes
Viral Meningitis
Arboviral Encephalitis
Genital Herpes
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology

