Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uncertainty, variability, and sensitivity analysis in physiological pharmacokinetic models

D Krewski1, Y Wang, S Bartlett

  • 1Health Protection Branch, Health Canada, Ottawa, Ontario, Canada.

Journal of Biopharmaceutical Statistics
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new system for custom helical mandibular distraction: a bench study on anatomical models.

International journal of oral and maxillofacial surgery·2026
Same author

On-site plant-wax biomarker analysis for assessing soil-organic-microbial degradation in archaeological contexts: A case study from Southern India.

iScience·2025
Same author

Critical review of the association between environmental manganese and thyroid function, with implications for potential neurodevelopmental effects.

Journal of toxicology and environmental health. Part B, Critical reviews·2025
Same author

Seasonally resolved stratigraphy at Jwalapuram India shows regional surface warming after the Toba volcanic super-eruption.

PNAS nexus·2025
Same author

A new system for custom helical mandibular distraction: a cadaver test.

International journal of oral and maxillofacial surgery·2025
Same author

Review of non-invasive biomarkers as a tool for exposure characterization in human health risk assessments.

Journal of toxicology and environmental health. Part B, Critical reviews·2024

Physiologically based pharmacokinetic (PBPK) models predict toxic chemical doses. This study proposes methods to assess parameter uncertainty and identify sensitive parameters for more accurate tissue dose predictions, using a benzene model example.

Area of Science:

  • Toxicology
  • Pharmacokinetics
  • Computational Modeling

Background:

  • Physiologically based pharmacokinetic (PBPK) models are crucial for predicting toxic metabolite doses in target tissues.
  • These complex models involve numerous parameters, each with inherent estimation errors.

Purpose of the Study:

  • To develop methods for assessing the impact of parameter uncertainty on PBPK model predictions of tissue dose.
  • To identify specific parameters to which PBPK model predictions are most sensitive.

Main Methods:

  • Proposed methods for uncertainty and sensitivity analysis in PBPK models.
  • Utilized a doubly truncated normal distribution to model body weight variation.
  • Applied methods to a PBPK model for benzene.

Related Experiment Videos

Main Results:

  • Demonstrated methods for quantifying the influence of parameter uncertainty on predicted tissue doses.
  • Identified key parameters driving sensitivity in PBPK predictions.
  • Illustrated the practical application of these methods using a benzene PBPK model.

Conclusions:

  • The proposed methods enhance the reliability of PBPK model predictions by addressing parameter uncertainty.
  • Sensitivity analysis helps refine PBPK models by focusing on critical parameters.
  • These approaches are vital for accurate risk assessment of chemical exposures.