Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genes involved in testicular development and function

D J Lamb1

  • 1Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.

World Journal of Urology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis.

Biochemistry and biophysics reports·2019
Same author

TRPV4 inhibition attenuates stretch-induced inflammatory cellular responses and lung barrier dysfunction during mechanical ventilation.

PloS one·2018
Same author

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.

Allergy·2016
Same author

The need to improve patient care through discriminate use of intracytoplasmic sperm injection (ICSI) and improved understanding of spermatozoa, oocyte and embryo biology.

Andrology·2015
Same author

Testosterone therapy and mortality risk.

International journal of impotence research·2014
Same author

Measurement of endothelial dysfunction via peripheral arterial tonometry predicts vasculogenic erectile dysfunction.

International journal of impotence research·2014
Same journal

Holmium laser enucleation of the prostate as salvage therapy for benign prostatic obstruction after multiple prior surgical interventions.

World journal of urology·2026
Same journal

Testing reliability of pubourethral ligament hemostat forceps support test for diagnosis of stress incontinence.

World journal of urology·2026
Same journal

Safety and efficacy of different surgical approaches in single-port robot-assisted radical prostatectomy based on propensity score matching analysis.

World journal of urology·2026
Same journal

Intrarenal pressure and clinical outcomes during suction-assisted versus conventional percutaneous nephrolithotomy: a systematic review and meta-analysis.

World journal of urology·2026
Same journal

AI-driven model for early failure prediction after HIFU integrating immediate post-ablation ultrasound and clinical data.

World journal of urology·2026
Same journal

Comment on "Nurse-led postoperative telemonitoring program following outpatient urethroplasty: a pilot study".

World journal of urology·2026
See all related articles

Testicular development relies on precise gene expression, including SRY, androgen receptors, and other factors. Proper function of these genes is crucial for male reproductive health and fertility.

Area of Science:

  • Reproductive Biology
  • Molecular Genetics
  • Developmental Biology

Background:

  • Testicular development involves complex gene regulation.
  • Transcription factors, steroid hormone receptors, and growth factors are key players.

Purpose of the Study:

  • To review the roles of specific genes in testicular development and function.
  • To highlight recent findings on SRY and its impact on testis determination.
  • To discuss the involvement of various gene families in male gonadal development.

Main Methods:

  • Gene cloning
  • Mutation analysis
  • Transgenic mice studies
  • Gene-deletion studies

Main Results:

Related Experiment Videos

  • SRY gene on the Y chromosome is essential for testis determination.
  • Androgen receptor gene defects cause male morphological defects.
  • Mutations in estrogen receptor and orphan receptors impact male fertility.
  • Tumor-suppressor genes and alpha-inhibin also play roles in testicular function.

Conclusions:

  • Normal testicular development and spermatogenesis require coordinated function of numerous genes.
  • These include transcription factors, steroid and orphan receptors, and growth factors.
  • Many genes essential for male gonadal development remain unidentified.